GLASS: a comprehensive database for experimentally validated GPCR-ligand associations.

ABSTRACT:

Motivation

G protein-coupled receptors (GPCRs) are probably the most attractive drug target membrane proteins, which constitute nearly half of drug targets in the contemporary drug discovery industry. While the majority of drug discovery studies employ existing GPCR and ligand interactions to identify new compounds, there remains a shortage of specific databases with precisely annotated GPCR-ligand associations.

Results

We have developed a new database, GLASS, which aims to provide a comprehensive, manually curated resource for experimentally validated GPCR-ligand associations. A new text-mining algorithm was proposed to collect GPCR-ligand interactions from the biomedical literature, which is then crosschecked with five primary pharmacological datasets, to enhance the cover

SUBMITTER: Chan WK 

PROVIDER: S-EPMC4668776 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature