Gastric Cancer: New Drugs - New Strategies.

ABSTRACT:

Background

Gastric cancer is the second most common cause of cancer-related deaths worldwide. There are large geographic variations in the incidence of these tumors, with 60% occurring in East Asia. For patients with resectable disease, surgery and perioperative treatment can be effective. For patients with advanced gastric cancer, chemotherapy regimens result in a median survival of 9-11 months. In general, the prognosis for advanced disease is poor and 5-year overall survival rates are around 15%. Combination therapies yield better survival rates, albeit with increased toxicity. Therefore, more effective and less toxic treatment regimens are needed.

Summary

The molecular aberrations that characterize the different subgroups of gastric cancer have been used as therapeutic t

SUBMITTER: Schulte N 

PROVIDER: S-EPMC4668795 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature