Ontology highlight
ABSTRACT:
SUBMITTER: Younger ST
PROVIDER: S-EPMC4668949 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Molecular bioSystems 20110518 8
Transcriptome studies have revealed that protein-coding loci within the human genome are overlapped at their 3'-termini by noncoding RNA (ncRNA) transcripts. Small duplex RNAs designed to be fully complementary to these 3' ncRNAs can modulate transcription of the upstream gene. Robust regulation by designed RNAs suggests that endogenous small RNAs might also recognize 3' ncRNAs and regulate gene expression. A genome-wide evaluation revealed that sequences immediately downstream of protein-coding ...[more]