RAB-10 Regulates Dendritic Branching by Balancing Dendritic Transport.

ABSTRACT: The construction of a large dendritic arbor requires robust growth and the precise delivery of membrane and protein cargoes to specific subcellular regions of the developing dendrite. How the microtubule-based vesicular trafficking and sorting systems are regulated to distribute these dendritic development factors throughout the dendrite is not well understood. Here we identify the small GTPase RAB-10 and the exocyst complex as critical regulators of dendrite morphogenesis and patterning in the C. elegans sensory neuron PVD. In rab-10 mutants, PVD dendritic branches are reduced in the posterior region of the cell but are excessive in the distal anterior region of the cell. We also demonstrate that the dendritic branch distribution within PVD depends on the balance between the molecular mot

SUBMITTER: Taylor CA 

PROVIDER: S-EPMC4669152 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature