Absolute Quantification of Human Liver Phosphorus-Containing Metabolites In Vivo Using an Inhomogeneous Spoiling Magnetic Field Gradient.

ABSTRACT:

Purpose

Absolute concentrations of high-energy phosphorus (31P) metabolites in liver provide more important insight into physiologic status of liver disease compared to resonance integral ratios. A simple method for measuring absolute concentrations of 31P metabolites in human liver is described. The approach uses surface spoiling inhomogeneous magnetic field gradient to select signal from liver tissue. The technique avoids issues caused by respiratory motion, chemical shift dispersion associated with linear magnetic field gradients, and increased tissue heat deposition due to radiofrequency absorption, especially at high field strength.

Methods

A method to localize signal from liver was demonstrated using superficial and highly non-uniform magnetic field gradients, which el

SUBMITTER: Bashir A 

PROVIDER: S-EPMC4669158 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature