The effect of antidepressant treatment on HIV and depression outcomes: results from a randomized trial.

ABSTRACT:

Background

Depression is a major barrier to HIV treatment outcomes.

Objective

To test whether antidepressant management decision support integrated into HIV care improves antiretroviral adherence and depression morbidity.

Design

Pseudo-cluster randomized trial.

Setting

Four US infectious diseases clinics.

Participants

HIV-infected adults with major depressive disorder.

Intervention

Measurement-based care (MBC) - depression care managers used systematic metrics to give HIV primary-care clinicians standardized antidepressant treatment recommendations.

Measurements

Primary - antiretroviral medication adherence (monthly unannounced telephone-based pill counts for 12 months). Primary time-point - 6 months. Secondary - depressive severity, depres

SUBMITTER: Pence BW 

PROVIDER: S-EPMC4669218 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature