Circulating Microparticles Alter Formation, Structure, and Properties of Fibrin Clots.

ABSTRACT: Despite the importance of circulating microparticles in haemostasis and thrombosis, there is limited evidence for potential causative effects of naturally produced cell-derived microparticles on fibrin clot formation and its properties. We studied the significance of blood microparticles for fibrin formation, structure, and susceptibility to fibrinolysis by removing them from platelet-free plasma using filtration. Clots made in platelet-free and microparticle-depleted plasma samples from the same healthy donors were analyzed in parallel. Microparticles accelerate fibrin polymerisation and support formation of more compact clots that resist internal and external fibrinolysis. These variations correlate with faster thrombin generation, suggesting thrombin-mediated kinetic effects of micropar

SUBMITTER: Zubairova LD 

PROVIDER: S-EPMC4669434 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature