Defining the Schistosoma haematobium kinome enables the prediction of essential kinases as anti-schistosome drug targets.

ABSTRACT: The blood fluke Schistosoma haematobium causes urogenital schistosomiasis, a neglected tropical disease (NTD) that affects more than 110 million people. Treating this disease by targeted or mass administration with a single chemical, praziquantel, carries the risk that drug resistance will develop in this pathogen. Therefore, there is an imperative to search for new drug targets in S. haematobium and other schistosomes. In this regard, protein kinases have potential, given their essential roles in biological processes and as targets for drugs already approved by the US Food and Drug Administration (FDA) for use in humans. In this context, we defined here the kinome of S. haematobium using a refined bioinformatic pipeline. We classified, curated and annotated predicted kinases, and assessed

SUBMITTER: Stroehlein AJ 

PROVIDER: S-EPMC4669435 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature