Telomere length and age-at-menopause in the US.

ABSTRACT:

Objectives

Age-at-menopause and leukocyte telomere length (LTL) are both associated with biologic aging. Therefore, it would be reasonable to hypothesize that LTL may also serve as a marker for reproductive aging as shorter LTL may be associated with earlier age-at-menopause.

Methods

We analyzed data from 799 post-menopausal (ages 41-85) participants in the National Health and Nutrition Examination Survey (1999-2002), a nationally representative sample of U.S. women.

Results

Controlling for behavioral, socio-demographic, and health-related determinants of menopause, we found that among non-Hispanic white women, an increase of one standard deviation in LTL was associated with a 0.43 year higher reported age-at-menopause. Among Mexican-Americans, an increase of one stan

SUBMITTER: Shenassa ED 

PROVIDER: S-EPMC4669569 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature