Tracing regulatory routes in metabolism using generalised supply-demand analysis.

ABSTRACT:

Background

Generalised supply-demand analysis is a conceptual framework that views metabolism as a molecular economy. Metabolic pathways are partitioned into so-called supply and demand blocks that produce and consume a particular intermediate metabolite. By studying the response of these reaction blocks to perturbations in the concentration of the linking metabolite, different regulatory routes of interaction between the metabolite and its supply and demand blocks can be identified and their contribution quantified. These responses are mediated not only through direct substrate/product interactions, but also through allosteric effects. Here we subject previously published kinetic models of pyruvate metabolism in Lactococcus lactis and aspartate-derived amino acid synthesis in Arab

SUBMITTER: Christensen CD 

PROVIDER: S-EPMC4669674 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature