Platelet-activating factor induces cell cycle arrest and disrupts the DNA damage response in mast cells.

ABSTRACT: Platelet-activating factor (PAF) is a potent phospholipid modulator of inflammation that has diverse physiological and pathological functions. Previously, we demonstrated that PAF has an essential role in ultraviolet (UV)-induced immunosuppression and reduces the repair of damaged DNA, suggesting that UV-induced PAF is contributing to skin cancer initiation by inducing immune suppression and also affecting a proper DNA damage response. The exact role of PAF in modulating cell proliferation, differentiation or transformation is unclear. Here, we investigated the mechanism(s) by which PAF affects the cell cycle and impairs early DNA damage response. PAF arrests proliferation in transformed and nontransformed human mast cells by reducing the expression of cyclin-B1 and promoting the expressio

SUBMITTER: Puebla-Osorio N 

PROVIDER: S-EPMC4669695 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature