Genome-wide mRNA and miRNA expression profiling reveal multiple regulatory networks in colorectal cancer.

ABSTRACT: Despite recent advances in cancer management, colorectal cancer (CRC) remains the third most common cancer and a major health-care problem worldwide. MicroRNAs have recently emerged as key regulators of cancer development and progression by targeting multiple cancer-related genes; however, such regulatory networks are not well characterized in CRC. Thus, the aim of this study was to perform global messenger RNA (mRNA) and microRNA expression profiling in the same CRC samples and adjacent normal tissues and to identify potential miRNA-mRNA regulatory networks. Our data revealed 1273 significantly upregulated and 1902 downregulated genes in CRC. Pathway analysis revealed significant enrichment in cell cycle, integrated cancer, Wnt (wingless-type MMTV integration site family member), matrix m

SUBMITTER: Vishnubalaji R 

PROVIDER: S-EPMC4669754 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature