Transcranial electric stimulation modulates firing rate at clinically relevant intensities.

ABSTRACT:

Background

Notwithstanding advances with low-intensity transcranial electrical stimulation (tES), there remain questions about the efficacy of clinically realistic electric fields on neuronal function.

Objective

To measure electric fields magnitude and their effects on neuronal firing rate of hippocampal neurons in freely moving rats, and to establish calibrated computational models of current flow.

Methods

Current flow models were calibrated on electric field measures in the motor cortex (n = 2 anesthetized rats) and hippocampus. A Neuropixels 2.0 probe with 384 channels was used in an in-vivo rat model of tES (n = 4 freely moving and 2 urethane anesthetized rats) to detect effects of weak fields on neuronal firing rate. High-density field mapping and computational m

SUBMITTER: Farahani F 

PROVIDER: S-EPMC466978 | biostudies-literature | 2024 May-Jun

REPOSITORIES: biostudies-literature