Association of vitamin D receptor gene polymorphisms with polycystic ovary syndrome among Indian women.

ABSTRACT:

Background & objectives

The Vitamin-D receptor (VDR) regulates vitamin D levels and calcium metabolism in the body and these are known to be associated with endocrine dysfunctions, insulin resistance and type-2 diabetes in polycystic ovarian syndrome (PCOS). Studies on VDR polymorphisms among PCOS women are sparse. We undertook this study to investigate the association pattern of VDR polymorphisms (Cdx2, Fok1, Apa1 and Taq1) with PCOS among Indian women.

Methods

For the present study, 250 women with PCOS and 250 normal healthy control women were selected from Hyderabad city, Telangana, India. The four VDR polymorphisms were genotyped and analysed using ASM-PCR (allele specific multiple PCR) and PCR-RFLP (restriction fragment length polymorphism).

Results

The genotype

SUBMITTER: Dasgupta S 

PROVIDER: S-EPMC4669862 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature