Gene Expression Switching of Receptor Subunits in Human Brain Development.

ABSTRACT: Synaptic receptors in the human brain consist of multiple protein subunits, many of which have multiple variants, coded by different genes, and are differentially expressed across brain regions and developmental stages. The brain can tune the electrophysiological properties of synapses to regulate plasticity and information processing by switching from one protein variant to another. Such condition-dependent variant switch during development has been demonstrated in several neurotransmitter systems including NMDA and GABA. Here we systematically detect pairs of receptor-subunit variants that switch during the lifetime of the human brain by analyzing postmortem expression data collected in a population of donors at various ages and brain regions measured using microarray and RNA-seq. To fur

SUBMITTER: Bar-Shira O 

PROVIDER: S-EPMC4670163 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature