Antibiotics promote inflammation through the translocation of native commensal colonic bacteria.

ABSTRACT:

Objective

Antibiotic use is associated with an increased risk of developing multiple inflammatory disorders, which in turn are linked to alterations in the intestinal microbiota. How these alterations in the intestinal microbiota translate into an increased risk for inflammatory responses is largely unknown. Here we investigated whether and how antibiotics promote inflammation via the translocation of live native gut commensal bacteria.

Design

Oral antibiotics were given to wildtype and induced mutant mouse strains, and the effects on bacterial translocation, inflammatory responses and the susceptibility to colitis were evaluated. The sources of the bacteria and the pathways required for bacterial translocation were evaluated using induced mutant mouse strains, 16s rRNA sequ

SUBMITTER: Knoop KA 

PROVIDER: S-EPMC4670297 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature