The correlation between pretreatment cytokine expression patterns in peripheral blood mononuclear cells with chronic hepatitis C outcome.

ABSTRACT:

Backgroud

Cytokine response against hepatitis C virus (HCV) is likely to determine the natural course of infection as well as the outcome of antiviral treatment. However, the role of particular cytokines remains unclear. The current study analyzed activation of cytokine response in chronic hepatitis C patients undergoing standard antiviral treatment.

Methods

Twenty-two patients were treated with pegylated interferon and ribavirin. Twenty-six different cytokine transcripts were measured quantitatively in peripheral blood mononuclear cells (PBMC) before and after therapy and correlated with therapy outcome as well as with clinical and liver histological data.

Results

We found that patients who achieved sustained virological response (SVR) showed higher pretreatment cyto

SUBMITTER: Jablonska J 

PROVIDER: S-EPMC4670510 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature