Ontology highlight
ABSTRACT:
SUBMITTER: Grabner A
PROVIDER: S-EPMC4670583 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Cell metabolism 20151001 6
Chronic kidney disease (CKD) is a worldwide public health threat that increases risk of death due to cardiovascular complications, including left ventricular hypertrophy (LVH). Novel therapeutic targets are needed to design treatments to alleviate the cardiovascular burden of CKD. Previously, we demonstrated that circulating concentrations of fibroblast growth factor (FGF) 23 rise progressively in CKD and induce LVH through an unknown FGF receptor (FGFR)-dependent mechanism. Here, we report that ...[more]