Systemic inflammation as a predictor of clinical outcomes after lower extremity angioplasty/stenting.

ABSTRACT:

Objective

The activation state of the systemic inflammatory milieu has been proposed as a critical regulator of vascular repair after injury. We evaluated the early inflammatory response after endovascular intervention for symptomatic peripheral arterial disease to determine its association with clinical success or failure.

Methods

Blood samples were obtained from 14 patients undergoing lower extremity angioplasty/stenting and analyzed using high-throughput gene arrays, multiplex serum protein analyses, and flow cytometry.

Results

Time-dependent plasma protein and monocyte phenotype analyses demonstrated endovascular revascularization had a modest influence on the overall activation state of the systemic inflammatory system, with baseline variability exceeding the per

SUBMITTER: DeSart K 

PROVIDER: S-EPMC4670612 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature