An experimentally supported model of the Bacillus subtilis global transcriptional regulatory network.

ABSTRACT: Organisms from all domains of life use gene regulation networks to control cell growth, identity, function, and responses to environmental challenges. Although accurate global regulatory models would provide critical evolutionary and functional insights, they remain incomplete, even for the best studied organisms. Efforts to build comprehensive networks are confounded by challenges including network scale, degree of connectivity, complexity of organism-environment interactions, and difficulty of estimating the activity of regulatory factors. Taking advantage of the large number of known regulatory interactions in Bacillus subtilis and two transcriptomics datasets (including one with 38 separate experiments collected specifically for this study), we use a new combination of network componen

SUBMITTER: Arrieta-Ortiz ML 

PROVIDER: S-EPMC4670728 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature