Skeletal muscle alterations in chronic heart failure: differential effects on quadriceps and diaphragm.

ABSTRACT:

Background

Chronic heart failure (CHF) results in limb and respiratory muscle weakness, which contributes to exercise intolerance and increased morbidity and mortality, yet the molecular mechanisms remain poorly understood. Therefore, we aimed to compare parameters of antioxidative capacity, energy metabolism, and catabolic/anabolic balance in diaphragm and quadriceps muscle in an animal model of CHF.

Methods

Ligation of the left anterior descending coronary artery (n = 13) or sham operation (n = 11) was performed on Wistar Kyoto rats. After 12 weeks, echocardiography and invasive determination of maximal rates of left ventricular (LV) pressure change were performed. Antioxidative and metabolic enzyme activities and expression of catabolic/anabolic markers were assessed in q

SUBMITTER: Mangner N 

PROVIDER: S-EPMC4670747 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature