Risk Stratification for Rejection and Infection after Kidney Transplantation.

ABSTRACT:

Background and objectives

Definition of individual risk profile is the first step to implement strategies to keep the delicate balance between under- and overimmunosuppression after kidney transplantation.

Design, setting, participants, & measurements

We used data from the Efficacy Limiting Toxicity Elimination Symphony Study (1190 patients between 2002 and 2004) to model risk of rejection and infection in the first year after kidney transplantation. External validation was performed in a study population from the Fixed-Dose Concentration-Controlled Trial (630 patients between 2003 and 2006).

Results

Despite different temporal dynamics, rejections and severe infections had similar overall incidences in the first year after transplantation (23.4% and 25.5%, respectivel

SUBMITTER: Cippa PE 

PROVIDER: S-EPMC4670759 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature