BP and Renal Outcomes in Diabetic Kidney Disease: The Veterans Affairs Nephropathy in Diabetes Trial.

ABSTRACT:

Background and objectives

Proteinuric diabetic kidney disease frequently progresses to ESRD. Control of BP delays progression, but the optimal BP to improve outcomes remains unclear. The objective of this analysis was to evaluate the relationship between BP and renal outcomes in proteinuric diabetic kidney disease.

Design, setting, participants, & measurements

BP data from all 1448 randomized participants in the Veterans Affairs Nephropathy in Diabetes Trial were included in a post hoc analysis. The associations of mean on-treatment BP with the primary end point (decline in eGFR, ESRD, or death), renal end point (decline in eGFR or ESRD), rate of eGFR decline, and mortality were measured.

Results

The median (25th, 75th percentile) follow-up time was 2.2 (1.2, 3.0) yea

SUBMITTER: Leehey DJ 

PROVIDER: S-EPMC4670761 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature