Arterial Stiffness and Decline in Kidney Function.

ABSTRACT:

Background and objectives

The independent link between arterial stiffness and CKD remains unknown. We investigated the association of indicators of arterial stiffness with decline in kidney function.

Design, setting, participants, & measurements

We studied 3666 participants (mean age =65 years old; 58% women) from the Rotterdam Study. Pulse pressure (PP), carotid stiffness, and pulse wave velocity (PWV) were measured. We created genetic risk scores for PP and PWV. Annual declines in kidney function and incident CKD were assessed using eGFR. To put our findings in context of the literature, we performed a meta-analysis of the available population-based studies.

Results

After a median (interquartile range) follow-up time of 11 (10.7-11.3) years, 601 participants with in

SUBMITTER: Sedaghat S 

PROVIDER: S-EPMC4670762 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature