Long-Term Risk of Cancer in Survivors of Pediatric ESRD.

ABSTRACT:

Background and objectives

ESRD is associated with an increased risk of malignancies. We analyzed the incidence of cancer in patients with pediatric ESRD after long-term follow-up.

Design, setting, participants, & measurements

All Dutch patients born before 1979 who were transplanted at age <15 years old in 1972-1992 were followed until 2010. We explored type and incidence of malignancies in patients compared with the general population using the National Cancer Registry.

Results

After a median of 25.3 years (1.3-37.8) of transplantation and at a median age of 33.5 years old (11.0-49.0), 105 primary malignancies had occurred in 54 of 249 patients. Among them, cutaneous squamous cell carcinoma was most frequent. Patients ages 25-30 years old had developed 16.5 times (95

SUBMITTER: Ploos van Amstel S 

PROVIDER: S-EPMC4670765 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature