Examination of Potential Modifiers of the Association of APOL1 Alleles with CKD Progression.

ABSTRACT:

Background and objectives

Common apolipoprotein L1 (APOL1) variants are associated with increased risk of progressive CKD; however, not all individuals with high-risk APOL1 variants experience CKD progression. Identification of factors contributing to heterogeneity has important scientific and clinical implications.

Design, setting, participants, & measurements

Using multivariable Cox models, we analyzed data from 693 participants in the African American Study of Kidney Disease and Hypertension to identify factors that modify the association between APOL1 genotypes and CKD progression (doubling of serum creatinine or incident ESRD).

Results

Participant mean age was 54 years old, median GFR was 49 ml/min per 1.73 m(2), and 23% had the APOL1 high-risk genotype (two copi

SUBMITTER: Chen TK 

PROVIDER: S-EPMC4670769 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature