The influence of type 1 diabetes on pancreatic weight.

ABSTRACT:

Aims/hypothesis

Previous studies of pancreases obtained at autopsy or by radiography note reduced pancreas weight (PW) and size, respectively, in type 1 diabetes; this finding is widely considered to be the result of chronic insulinopenia. This literature is, however, limited with respect to the influence of age, sex, anthropometric factors and disease duration on these observations. Moreover, data are sparse for young children, a group of particular interest for type 1 diabetes. We hypothesised that the pancreas-to-body weight ratio would normalise confounding inter-subject factors, thereby permitting better characterisation of PW in type 1 diabetes.

Methods

Transplant-grade pancreases were recovered from 216 organ donors with type 1 diabetes (n = 90), type 2 diabetes (n = 

SUBMITTER: Campbell-Thompson ML 

PROVIDER: S-EPMC4670792 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature