Genital Human Papillomavirus Infection Progression to External Genital Lesions: The HIM Study.

ABSTRACT:

Background

Human papillomavirus (HPV) causes two types of external genital lesions (EGLs) in men: genital warts (condyloma) and penile intraepithelial neoplasia (PeIN).

Objective

The purpose of this study was to describe genital HPV progression to a histopathologically confirmed HPV-related EGL.

Design, setting, and participants

A prospective analysis nested within the HPV Infection in Men (HIM) study was conducted among 3033 men. At each visit, visually distinct EGLs were biopsied; the biopsy specimens were subjected to pathologic evaluation and categorized by pathologic diagnoses. Genital swabs and biopsies were used to identify HPV types using the Linear Array genotyping method for swabs and INNO-LiPA for biopsy specimens.

Outcome measurements and statistical an

SUBMITTER: Sudenga SL 

PROVIDER: S-EPMC4670812 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature