Extent of flow recirculation governs expression of atherosclerotic and thrombotic biomarkers in arterial bifurcations.

ABSTRACT:

Aims

Atherogenesis, evolution of plaque, and outcomes following endovascular intervention depend heavily on the unique vascular architecture of each individual. Patient-specific, multiscale models able to correlate changes in microscopic cellular responses with relevant macroscopic flow, and structural conditions may help understand the progression of occlusive arterial disease, providing insights into how to mitigate adverse responses in specific settings and individuals.

Methods and results

Vascular architectures mimicking coronary and carotid bifurcations were derived from clinical imaging and used to generate conjoint computational meshes for in silico analysis and biocompatible scaffolds for in vitro models. In parallel with three-dimensional flow simulations, geometric

SUBMITTER: Martorell J 

PROVIDER: S-EPMC4670884 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature