Comparison of peg-interferon, ribavirin plus telaprevir vs simeprevir by propensity score matching.

ABSTRACT:

Aim

To compare efficacy of telaprevir (TVR) and simeprevir (SMV) combined with pegylated interferon (PEG-IFN) and ribavirin (RBV) while treating chronic hepatitis C (CHC).

Methods

In all, 306 CHC patients were included in this study. There were 159 patients in the TVR combination therapy group and 147 patients in the SMV combination therapy group. To evaluate pretreatment factors contributing to sustained virological response at 12 wk (SVR12), univariate and multivariate analyses were performed in TVR and SMV groups. To adjust for patient background between TVR and SMV groups, propensity score matching was performed. Virological response during treatment and SVR12 were evaluated.

Results

Overall rates of SVR12 [undetectable serum hepatitis C virus (HCV) RNA levels] we

SUBMITTER: Fujii H 

PROVIDER: S-EPMC4670956 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature