A novel SPECT-based approach reveals early mechanisms of central and peripheral inflammation after cerebral ischemia.

ABSTRACT: Inflammation that develops in the brain and peripheral organs after stroke contributes profoundly to poor outcome of patients. However, mechanisms through which inflammation impacts on brain injury and overall outcome are improperly understood, in part because the earliest inflammatory events after brain injury are not revealed by current imaging tools. Here, we show that single-photon emission computed tomography (NanoSPECT/CT Plus) allows visualization of blood brain barrier (BBB) injury after experimental stroke well before changes can be detected with magnetic resonance imaging (MRI). Early 99mTc-DTPA (diethylene triamine pentaacetic acid) signal changes predict infarct development and systemic inflammation preceding experimental stroke leads to very early perfusion deficits and increa

SUBMITTER: Szigeti K 

PROVIDER: S-EPMC4671129 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature