A Unified Probabilistic Framework for Dose-Response Assessment of Human Health Effects.

ABSTRACT:

Background

When chemical health hazards have been identified, probabilistic dose-response assessment ("hazard characterization") quantifies uncertainty and/or variability in toxicity as a function of human exposure. Existing probabilistic approaches differ for different types of endpoints or modes-of-action, lacking a unifying framework.

Objectives

We developed a unified framework for probabilistic dose-response assessment.

Methods

We established a framework based on four principles: a) individual and population dose responses are distinct; b) dose-response relationships for all (including quantal) endpoints can be recast as relating to an underlying continuous measure of response at the individual level; c) for effects relevant to humans, "effect metrics" can be spec

SUBMITTER: Chiu WA 

PROVIDER: S-EPMC4671238 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature