Bidirectional Transfer Study of Polystyrene Nanoparticles across the Placental Barrier in an ex Vivo Human Placental Perfusion Model.

ABSTRACT:

Background

Nanoparticle exposure in utero might not be a major concern yet, but it could become more important with the increasing application of nanomaterials in consumer and medical products. Several epidemiologic and in vitro studies have shown that nanoparticles can have potential toxic effects. However, nanoparticles also offer the opportunity to develop new therapeutic strategies to treat specifically either the pregnant mother or the fetus. Previous studies mainly addressed whether nanoparticles are able to cross the placental barrier. However, the transport mechanisms underlying nanoparticle translocation across the placenta are still unknown.

Objectives

In this study we examined which transport mechanisms underlie the placental transfer of nanoparticles.

Methods<

SUBMITTER: Grafmueller S 

PROVIDER: S-EPMC4671239 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature