Alzheimer's Genetic Risk Intensifies Neurocognitive Slowing Associated with Diabetes in Non-Demented Older Adults.

ABSTRACT:

Introduction

We examine interactive and intensification effects of type 2 diabetes (T2D) with APOE and an Alzheimer's disease Genetic Risk Score (GRS) on neurocognitive speed performance and change in non-demented older adults.

Methods

In an accelerated longitudinal design, we used latent growth modeling to test moderators of level and change in a neurocognitive speed latent variable for 628 adults (baseline M age=69.0) followed over 9 years. The GRS was compiled using the cumulative risk of APOE, CLU, CR1, and PICALM.

Results

First, T2D predicted slower speed performance at centering age (75). Second, no predictive effects were associated with APOE or GRS. Third, a significant interaction showed that high risk from both T2D a

SUBMITTER: McFall GP 

PROVIDER: S-EPMC4671298 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature