Single unit action potentials in humans and the effect of seizure activity.

ABSTRACT: Spike-sorting algorithms have been used to identify the firing patterns of isolated neurons ('single units') from implanted electrode recordings in patients undergoing assessment for epilepsy surgery, but we do not know their potential for providing helpful clinical information. It is important therefore to characterize both the stability of these recordings and also their context. A critical consideration is where the units are located with respect to the focus of the pathology. Recent analyses of neuronal spiking activity, recorded over extended spatial areas using microelectrode arrays, have demonstrated the importance of considering seizure activity in terms of two distinct spatial territories: the ictal core and penumbral territories. The pathological information in these two areas, h

SUBMITTER: Merricks EM 

PROVIDER: S-EPMC4671476 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature