Dauer-specific dendrite arborization in C. elegans is regulated by KPC-1/Furin.

ABSTRACT:

Background

Dendrites often display remarkably complex and diverse morphologies that are influenced by developmental and environmental cues. Neuroplasticity in response to adverse environmental conditions entails both hypertrophy and resorption of dendrites. How dendrites rapidly alter morphology in response to unfavorable environmental conditions is unclear. The nematode Caenorhabditis elegans enters into a stress-resistant dauer larval stage in response to an adverse environment.

Results

Here we show that the IL2 bipolar sensory neurons undergo dendrite arborization and axon remodeling during dauer development. When dauer larvae are returned to favorable environmental conditions, animals resume reproductive development and IL2 dendritic branches retract, leaving behind remn

SUBMITTER: Schroeder NE 

PROVIDER: S-EPMC4671503 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature