Effect of glaucoma medications on 24-hour intraocular pressure-related patterns using a contact lens sensor.

ABSTRACT:

Background

The aim of this article was to study the circadian intraocular pressure (IOP)-related effects of ocular hypotensive medications using a contact lens sensor (CLS).

Design

This is a university-based prospective, randomized, crossover trial.

Participants

A total of 23 patients with primary open-angle glaucoma participated.

Methods

Patients underwent ambulatory recording of IOP-related patterns for 24 h in one eye during 3 monthly sessions using a CLS. Patients were untreated in session 1 (S1), were randomized to one of four classes of glaucoma drops for S2 and had a prostaglandin analogue add-on for S3.

Main outcome measures

Changes in IOP-related patterns were defined using (i) slopes from wake/sitting to sleep/supine; (ii) cosinor rhythmometry

SUBMITTER: Mansouri K 

PROVIDER: S-EPMC4671823 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature