Network-Dependent Modulation of COMT and DRD2 Polymorphisms in Healthy Young Adults.

ABSTRACT: Nonlinear modulation of the dopamine signaling on brain functions can be estimated by the interaction effects of dopamine-related genetic variations. We aimed to explore the interaction effects of COMT rs4680 and DRD2 rs1076560 on intra-network connectivity using independent component analysis. In 250 young healthy adults, we identified 11 meaningful resting-state networks (RSNs), including the salience, visual, auditory, default-mode, sensorimotor, attention and frontoparietal networks. A two-way analysis of covariance was used to investigate COMT×DRD2 interactions on intra-network connectivity in each network, controlling for age, gender and education. Significant COMT×DRD2 interaction was found in intra-network connectivity in the left medial prefrontal cortex of the anterior default-mo

SUBMITTER: Zhao F 

PROVIDER: S-EPMC4672286 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature