The Haemonchus contortus kinome--a resource for fundamental molecular investigations and drug discovery.

ABSTRACT:

Background

Protein kinases regulate a plethora of essential signalling and other biological pathways in all eukaryotic organisms, but very little is known about them in most parasitic nematodes.

Methods

Here, we defined, for the first time, the entire complement of protein kinases (kinome) encoded in the barber's pole worm (Haemonchus contortus) through an integrated analysis of transcriptomic and genomic datasets using an advanced bioinformatic workflow.

Results

We identified, curated and classified 432 kinases representing ten groups, 103 distinct families and 98 subfamilies. A comparison of the kinomes of H. contortus and Caenorhabditis elegans (a related, free-living nematode) revealed considerable variation in the numbers of casein kinases, tyrosine kinases and C

SUBMITTER: Stroehlein AJ 

PROVIDER: S-EPMC4672506 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature