De novo transcriptome reconstruction and annotation of the Egyptian rousette bat.

ABSTRACT:

Background

The Egyptian Rousette bat (Rousettus aegyptiacus), a common fruit bat species found throughout Africa and the Middle East, was recently identified as a natural reservoir host of Marburg virus. With Ebola virus, Marburg virus is a member of the family Filoviridae that causes severe hemorrhagic fever disease in humans and nonhuman primates, but results in little to no pathological consequences in bats. Understanding host-pathogen interactions within reservoir host species and how it differs from hosts that experience severe disease is an important aspect of evaluating viral pathogenesis and developing novel therapeutics and methods of prevention.

Results

Progress in studying bat reservoir host responses to virus infection is hampered by the lack of host-specific rea

SUBMITTER: Lee AK 

PROVIDER: S-EPMC4672546 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature