HDAC6 activity is a non-oncogene addiction hub for inflammatory breast cancers.

ABSTRACT:

Introduction

Inflammatory breast cancer (IBC) is the most lethal form of breast cancers with a 5-year survival rate of only 40 %. Despite its lethality, IBC remains poorly understood which has greatly limited its therapeutic management. We thus decided to utilize an integrative functional genomic strategy to identify the Achilles' heel of IBC cells.

Methods

We have pioneered the development of genetic tools as well as experimental and analytical strategies to perform RNAi-based loss-of-function studies at a genome-wide level. Importantly, we and others have demonstrated that these functional screens are able to identify essential functions linked to certain cancer phenotypes. Thus, we decided to use this approach to identify IBC specific sensitivities.

Results

We iden

SUBMITTER: Putcha P 

PROVIDER: S-EPMC4672555 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature