Genomic and transcriptomic predictors of triglyceride response to regular exercise.

ABSTRACT:

Aim

We performed genome-wide and transcriptome-wide profiling to identify genes and single nucleotide polymorphisms (SNPs) associated with the response of triglycerides (TG) to exercise training.

Methods

Plasma TG levels were measured before and after a 20-week endurance training programme in 478 white participants from the HERITAGE Family Study. Illumina HumanCNV370-Quad v3.0 BeadChips were genotyped using the Illumina BeadStation 500GX platform. Affymetrix HG-U133+2 arrays were used to quantitate gene expression levels from baseline muscle biopsies of a subset of participants (N=52). Genome-wide association study (GWAS) analysis was performed using MERLIN, while transcriptomic predictor models were developed using the R-package GALGO.

Results

The GWAS results showed

SUBMITTER: Sarzynski MA 

PROVIDER: S-EPMC4672639 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature