Convergent genetic and expression data implicate immunity in Alzheimer's disease.

ABSTRACT:

Background

Late-onset Alzheimer's disease (AD) is heritable with 20 genes showing genome-wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underlying the disease, we extended these genetic data in a pathway analysis.

Methods

The ALIGATOR and GSEA algorithms were used in the IGAP data to identify associated functional pathways and correlated gene expression networks in human brain.

Results

ALIGATOR identified an excess of curated biological pathways showing enrichment of association. Enriched areas of biology included the immune response (P = 3.27 × 10(-12) after multiple testing correction for pathways), regulation of endocytosis (P = 1.31 × 10(-11)), cholesterol transport (P = 2.96 × 10(-9)), and proteasome-ubiquiti

SUBMITTER: International Genomics of Alzheimer's Disease Consortium (IGAP) 

PROVIDER: S-EPMC4672734 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature