Ontology highlight
ABSTRACT:
SUBMITTER: Cannon CM
PROVIDER: S-EPMC4672990 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Veterinary and comparative oncology 20130215 1
We evaluated the effect of Aurora kinase inhibitors AZD1152 and VX680 on canine osteosarcoma cells. Cytotoxicity was seen in all four cell lines; however, half-maximal inhibitory concentrations were significantly higher than in human leukaemia and canine lymphoma cells. AZD1152 reduced Aurora kinase B phosphorylation, indicating resistance was not because of failure of target recognition. Efflux mediated by ABCB1 and ABCG2 transporters is one known mechanism of resistance against these drugs and ...[more]