Measurement of serum prostate cancer markers using a nanopore thin film based optofluidic chip.

ABSTRACT: Currently used cancer marker for prostate adenocarcinoma (PC), serum prostate-specific antigen (PSA), greatly overestimates PC population. Patients with high PSA levels have to undergo unnecessary but physically painful and expensive procedure such as prostate biopsies repeatedly. The reliability of PC test can be greatly increased by finding a protein that is secreted selectively by malignant, but not normal, prostate cells. A recently discovered novel protein, referred as neuroendocrine marker (NEM), is secreted only by malignant prostate cells and released in blood circulation. Although NEM seems to be significantly more reliable based on the data obtained from a limited cohort, currently available NEM ELISA is not suitable for undertaking a large study. Therefore, the goal of the prese

SUBMITTER: Alzghoul S 

PROVIDER: S-EPMC4673024 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature