Local brain connectivity across development in autism spectrum disorder: A cross-sectional investigation.

ABSTRACT: There is a general consensus that autism spectrum disorder (ASD) is accompanied by alterations in brain connectivity. Much of the neuroimaging work has focused on assessing long-range connectivity disruptions in ASD. However, evidence from both animal models and postmortem examination of the human brain suggests that local connections may also be disrupted in individuals with the disorder. Here, we investigated how regional homogeneity (ReHo), a measure of similarity of a voxel's timeseries to its nearest neighbors, varies across age in individuals with ASD and typically developing (TD) individuals using a cross-sectional design. Resting-state fMRI data obtained from a publicly available database were analyzed to determine group differences in ReHo between three age cohorts: children, adol

SUBMITTER: Dajani DR 

PROVIDER: S-EPMC4673031 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature