Effect of tumor size on breast cancer-specific survival stratified by joint hormone receptor status in a SEER population-based study.

ABSTRACT:

Background & aims

The prognostic value of tumor size is variable. We aimed to characterize the interaction between tumor size and hormone receptor (HoR) status to determine breast cancer-specific mortality (BCSM).

Methods

We used the Surveillance, Epidemiology and End Results (SEER) registry to identify 328, 870 female patients diagnosed with invasive breast cancer from 1990 through 2010. Primary study variables included tumor size, joint HoR status and their corresponding relationship. Kaplan-Meier and adjusted Cox proportional hazards models with interaction terms were utilized.

Results

The multivariable analysis revealed a significant interaction between tumor size and HoR status (P < 0.001). Using tumors 61-70 mm in size as the reference for estrogen receptor-nega

SUBMITTER: Zheng YZ 

PROVIDER: S-EPMC4673215 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature