Intestinal microbiota composition after antibiotic treatment in early life: the INCA study.

ABSTRACT:

Background

The acquisition and development of infant gut microbiota can be influenced by numerous factors, of which early antibiotic treatment is an important one. However, studies on the effects of antibiotic treatment in early life on clinical outcomes and establishment and development of the gut microbiota of term infants are limited. Disturbed microbiota composition is hypothesized to be an underlying mechanism of an aberrant development of the immune system. This study aims to investigate the potential clinical and microbial consequences of empiric antibiotic use in early life.

Methods/design

450 term born infants, of whom 150 are exposed to antibiotic treatment in early life and 300 are not (control group), are included in this observational cohort study with a one-yea

SUBMITTER: Rutten NB 

PROVIDER: S-EPMC4673740 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature