Ontology highlight
ABSTRACT:
SUBMITTER: Stadhouders R
PROVIDER: S-EPMC4673834 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Nature communications 20151123
How transcription factors (TFs) cooperate within large protein complexes to allow rapid modulation of gene expression during development is still largely unknown. Here we show that the key haematopoietic LIM-domain-binding protein-1 (LDB1) TF complex contains several activator and repressor components that together maintain an erythroid-specific gene expression programme primed for rapid activation until differentiation is induced. A combination of proteomics, functional genomics and in vivo stu ...[more]