Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke: The NHLBI Exome Sequence Project.

ABSTRACT:

Importance

Stroke is the second leading cause of death and the third leading cause of years of life lost. Genetic factors contribute to stroke prevalence, and candidate gene and genome-wide association studies (GWAS) have identified variants associated with ischemic stroke risk. These variants often have small effects without obvious biological significance. Exome sequencing may discover predicted protein-altering variants with a potentially large effect on ischemic stroke risk.

Objective

To investigate the contribution of rare and common genetic variants to ischemic stroke risk by targeting the protein-coding regions of the human genome.

Design, setting, and participants

The National Heart, Lung, and Blood Institute (NHLBI) Exome Sequencing Project (ESP) analyzed app

SUBMITTER: Auer PL 

PROVIDER: S-EPMC4673986 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature